CEBP Alpha (CEBPA) Rabbit Polyclonal Antibody

CAT#: TA322760

Anti-CEBPA Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-100
  Positive control: Human tonsil
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 82-100 amino acids of Human CCAAT/enhancer binding protein (C/EBP), alpha
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CCAAT/enhancer binding protein alpha
• Database Link:
  NP_004355
  Entrez Gene 12606 MouseEntrez Gene 24252 RatEntrez Gene 1050 Human
  UniProt ID P49715
• Background: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin; a protein that plays an important role in body weight homeostasis. Also; the encoded protein can interact with CDK2 and CDK4; thereby inhibiting these kinases and causing growth arrest in cultured cells.
• Synonyms: C; CEBP; EBP-alpha

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer