RUNX3 Rabbit Polyclonal Antibody

CAT#: TA322761

Anti-RUNX3 rabbit polyclonal antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: HL-60 and Jurkat cell lysates
  IHC: 20-100
  Positive control: Human tonsil
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 400-415 amino acids of human runt-related transcription factor 3
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 44 kDa
• Gene Name: runt related transcription factor 3
• Database Link:
  NP_004341
  Entrez Gene 12399 MouseEntrez Gene 156726 RatEntrez Gene 864 Human
  UniProt ID Q13761
• Background: This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• Synonyms: AML2; CBFA3; PEBP2aC

Reference Data

• Protein Families: Transcription Factors