Caldesmon (CALD1) Rabbit Polyclonal Antibody

CAT#: TA322765

Anti-CALD1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 50-150
  Positive control: Human lung cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 26-207 amino acids of human caldesmon 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caldesmon 1
• Database Link:
  NP_149347
  Entrez Gene 25687 RatEntrez Gene 109624 MouseEntrez Gene 800 Human
  UniProt ID Q05682
• Background: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin; actin; tropomyosin; myosin; and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase; and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.?
• Synonyms: CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22

Reference Data

• Protein Pathways: Vascular smooth muscle contraction