Caldesmon (CALD1) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | ELISA, IHC |
Recommended Dilution | IHC: 50-150 Positive control: Human lung cancer Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Fusion protein corresponding to a region derived from 26-207 amino acids of human caldesmon 1 |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | caldesmon 1 |
Database Link | |
Background | This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin; actin; tropomyosin; myosin; and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase; and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.? |
Synonyms | CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22 |
Reference Data | |
Protein Pathways | Vascular smooth muscle contraction |
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