BCR Rabbit Polyclonal Antibody
Other products for "BCR"
Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | WB: 1:500-1000, IF: 1:100-200 |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Peptide sequence around aa. 175~179 (P-F-Y-V-N) derived from Human Bcr. |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | BCR, RhoGEF and GTPase activating protein |
Database Link | |
Background | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. |
Synonyms | ALL; BCR1; CML; D22S11; D22S662; PHL |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Chronic myeloid leukemia, Pathways in cancer |
Documents
Product Manuals |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.