ALK Rabbit Polyclonal Antibody

CAT#: TA322771

Anti-ALK Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA322771 (ALK Antibody) at dilution 1/25. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322771 (ALK Antibody) at dilution 1/25. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human cervical cancer
  Predicted cell location: Cell membrane, Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 650-664 amino acids of Human ALK tyrosine kinase receptor
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: anaplastic lymphoma receptor tyrosine kinase
• Database Link:
  NP_004295
  Entrez Gene 11682 MouseEntrez Gene 266802 RatEntrez Gene 238 Human
  UniProt ID Q9UM73
• Background: This gene encodes a receptor tyrosine kinase; which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain; an hydrophobic stretch corresponding to a single pass transmembrane region; and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged; mutated; or amplified in a series of tumours including anaplastic large cell lymphomas; neuroblastoma; and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene; which result in creation of multiple fusion genes in tumourigenesis; including ALK (chromosome 2)/EML4 (chromosome 2); ALK/RANBP2 (chromosome 2); ALK/ATIC (chromosome 2); ALK/TFG (chromosome 3); ALK/NPM1 (chromosome 5); ALK/SQSTM1 (chromosome 5); ALK/KIF5B (chromosome 10); ALK/CLTC (chromosome 17); ALK/TPM4 (chromosome 19); and ALK/MSN (chromosome X).
• Synonyms: CD246; NBLST3

Reference Data

• Protein Families: Druggable Genome, Protein Kinase