Securin (PTTG1) Rabbit Polyclonal Antibody
Other products for "PTTG1"
Specifications
Product Data | |
Applications | IHC |
Recommended Dilution | IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 99-112 amino acids of human |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | pituitary tumor-transforming 1 |
Database Link | |
Background | The encoded protein is a homolog of yeast securin proteins; which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo; and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs; which are required for its transforming and tumorigenic activities; as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein; although it partially localizes in the nucleus. |
Synonyms | EAP1; HPTTG; PTTG; TUTR1 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Cell cycle, Oocyte meiosis |
Documents
Product Manuals |
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