alpha Defensin 1 (DEFA1) Rabbit Polyclonal Antibody

CAT#: TA322802

Anti-DEFA1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322802 (DEFA1 Antibody) at dilution 1/10 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322802 (DEFA1 Antibody) at dilution 1/10, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5-20
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 49-63 amino acids of Human Defensin, alpha 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: defensin alpha 1
• Database Link:
  NP_004075
  Entrez Gene 13216 MouseEntrez Gene 1667 Human
  UniProt ID P59665
• Background: Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine; respiratory tract; urinary tract; and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene; defensin; alpha 1; is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin; alpha 3 by only one amino acid. This gene and the gene encoding defensin; alpha 3 are both subject to copy number variation.
• Synonyms: DEF1; DEFA2; HNP-1; HP-1; HP1; MRS

Reference Data

• Protein Families: Druggable Genome, Secreted Protein