RHOB Rabbit Polyclonal Antibody

CAT#: TA322808

Anti-RHOB Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1000-2000
  WB positive control: Mouse brain and fetal brain tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 179-188 amino acids of Human Ras homolog family member B
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kDa
• Gene Name: ras homolog family member B
• Database Link:
  NP_004031
  Entrez Gene 11852 MouseEntrez Gene 64373 RatEntrez Gene 388 Human
  UniProt ID P62745
• Background: Ras homolog gene family; member B; also known as RHOB; is a protein which in humans is encoded by the RHOB gene.RHOB is a member of the Rho GTP-binding protein family.Mediates apoptosis in neoplastically transformed cells after DNA damage. It is not necessary for development but affects cell adhesion and growth factor signaling in transformed cells. It plays a negative role in tumorigenesis as deletion causes tumor formation. It involved in intracellular protein trafficking of a number of proteins; and serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
• Synonyms: ARH6; ARHB; MST081; MSTP081; RHOH6

Reference Data

• Protein Families: Druggable Genome