TIMP1 Rabbit Polyclonal Antibody

CAT#: TA322880

Anti-TIMP1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 15-50
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 24-207 amino acids of human TIMP metallopeptidase inhibitor 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TIMP metallopeptidase inhibitor 1
• Database Link:
  NP_003245
  Entrez Gene 21857 MouseEntrez Gene 116510 RatEntrez Gene 7076 Human
  UniProt ID P01033
• Background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs); a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs; the encoded protein is able to promote cell proliferation in a wide range of cell types; and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition; the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
• Synonyms: CLGI; EPA; EPO; HCI; TIMP; TIMP-1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein