Synaptotagmin V (SYT5) Rabbit Polyclonal Antibody

CAT#: TA322890

Anti-SYT5 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human cerebrum tissue lysate
  IHC: 50-200
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 46-200 amino acids of human synaptotagmin V
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 43 kDa
• Gene Name: synaptotagmin 5
• Database Link:
  NP_003171
  Entrez Gene 53420 MouseEntrez Gene 54309 RatEntrez Gene 6861 Human
  UniProt ID O00445
• Background: Synaptotagmins; such as SYT5; are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C regulatory (C2) domains; which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion; allowing fusion in the presence of calcium; and as calcium receptors or sensor molecules. May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.
• Synonyms: synaptotagmin 5; synaptotagmin V

Reference Data

• Protein Families: Secreted Protein, Transmembrane