RAB6A Rabbit Polyclonal Antibody

CAT#: TA322943

Anti-RAB6A Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: 293T cells and mouse brain tissue, A549, Hela, A172 and HT-29 cells
  IHC: 25-100
  Positive control: Human skin
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 125-139 amino acids of Human Ras-related protein Rab-6A
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 24 kDa
• Gene Name: RAB6A, member RAS oncogene family
• Database Link:
  NP_002860
  Entrez Gene 19346 MouseEntrez Gene 84379 RatEntrez Gene 5870 Human
  UniProt ID P20340
• Background: This gene encodes a member of the RAB family; which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus; which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1; which interacts with the HCMV virion tegument protein; pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Synonyms: RAB6

Reference Data

• Protein Families: Druggable Genome