MMP3 Rabbit Polyclonal Antibody

CAT#: TA323014

Anti-MMP3 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA323014 (MMP3 Antibody) at dilution 1/10. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA323014 (MMP3 Antibody) at dilution 1/10. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 350 amino acids of Human Matrix metalloproteinase-3
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: matrix metallopeptidase 3
• Database Link:
  NP_002413
  Entrez Gene 17392 MouseEntrez Gene 171045 RatEntrez Gene 4314 Human
  UniProt ID P08254
• Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes; such as embryonic development; reproduction; and tissue remodeling; as well as in disease processes; such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin; laminin; collagens III; IV; IX; and X; and cartilage proteoglycans. The enzyme is thought to be involved in wound repair; progression of atherosclerosis; and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
• Synonyms: CHDS6; MMP-3; SL-1; STMY; STMY1; STR1

Reference Data

• Protein Families: Druggable Genome, Protease