KCNA5 Rabbit Polyclonal Antibody

CAT#: TA323044

Anti-KCNA5 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 40 μg Lane: Mouse spleen tissue Primary antibody: TA323044 (KCNA5 Antibody) at dilution 1/700 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 60 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse spleen tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 517-613 amino acids of human potassium voltage-gated channel, shaker-related subfamily, member 5
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 44 kDa
• Gene Name: potassium voltage-gated channel subfamily A member 5
• Database Link:
  NP_002225
  Entrez Gene 16493 MouseEntrez Gene 25470 RatEntrez Gene 3741 Human
  UniProt ID P22460
• Background: Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release; heart rate; insulin secretion; neuronal excitability; epithelial electrolyte transport; smooth muscle contraction; and cell volume. Four sequence-related potassium channel genes - shaker; shaw; shab; and shal - have been identified in Drosophila; and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel; voltage-gated; shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class; the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless; and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).?
• Synonyms: ATFB7; HCK1; HK2; HPCN1; KV1.5; PCN1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane