VEGF Receptor 1 (FLT1) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | IF |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 1303-1316 amino acids of human fms-related tyrosine kinase 1 |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | fms related tyrosine kinase 1 |
Database Link | |
Background | This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains; a transmembrane segment; and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A; VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells; placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened; soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia. |
Synonyms | FLT; FLT-1; VEGFR-1; VEGFR1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion |
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