Collagen II (COL2A1) Rabbit Polyclonal Antibody

CAT#: TA323106

Anti-COL2A1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Rat skeletal muscle tissue lysate
  IHC: 50-200
  Positive control: Human liver cancer
  Predicted cell location: Secreted
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 30 kDa
• Gene Name: collagen type II alpha 1 chain
• Database Link:
  NP_001835
  Entrez Gene 12824 MouseEntrez Gene 25412 RatEntrez Gene 1280 Human
  UniProt ID P02458
• Background: This gene encodes the alpha-1 chain of type II collagen; a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis; chondrodysplasia; early onset familial osteoarthritis; SED congenita; Langer-Saldino achondrogenesis; Kniest dysplasia; Stickler syndrome type I; and spondyloepimetaphyseal dysplasia Strudwick type. In addition; defects in processing chondrocalcin; a calcium binding protein that is the C-propeptide of this collagen molecule; are also associated with chondrodysplasia. There are two transcripts identified for this gene.
• Synonyms: ANFH; AOM; COL11A3; SEDC; STL1

Reference Data

• Protein Pathways: ECM-receptor interaction, Focal adhesion