CDC25A Rabbit Polyclonal Antibody

CAT#: TA323117

Anti-CDC25A Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse heart tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 376-482 amino acids of human cell division cycle 25 homolog A (S. pombe)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa
• Gene Name: cell division cycle 25A
• Database Link:
  NP_001780
  Entrez Gene 12530 MouseEntrez Gene 171102 RatEntrez Gene 993 Human
  UniProt ID P30304
• Background: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage; which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene; although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.?
• Synonyms: CDC25A2

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Cell cycle, Progesterone-mediated oocyte maturation