CRMP2 (DPYSL2) Rabbit Polyclonal Antibody

CAT#: TA323185

Anti-DPYSL2 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: NIH/3T3 cells
  IHC: 25-100
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 476-493 amino acids of Human Collapsin response mediator protein 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 62 kDa
• Gene Name: dihydropyrimidinase like 2
• Database Link:
  NP_001377
  Entrez Gene 12934 MouseEntrez Gene 25416 RatEntrez Gene 1808 Human
  UniProt ID Q16555
• Background: This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance; growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse; and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders; and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Synonyms: CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance