Claudin 7 (CLDN7) Rabbit Polyclonal Antibody

CAT#: TA323192

Anti-CLDN7 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 30 μg Lane: Human liver cancer tissue Primary antibody: TA323192 (CLDN7 Antibody) at dilution 1/1050 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 40 seconds

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA323192 (CLDN7 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA323192 (CLDN7 Antibody) at dilution 1/50, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human stomach cancer tissue using TA323192 (CLDN7 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human stomach cancer tissue using TA323192 (CLDN7 Antibody) at dilution 1/50, treated with synthetic peptide. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1000-3000
  WB positive control: Human liver cancer tissue
  IHC: 50-150
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 199-212 amino acids of Human claudin 7
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 23 kDa
• Gene Name: claudin 7
• Database Link:
  NP_001298
  Entrez Gene 53624 MouseEntrez Gene 65132 RatEntrez Gene 1366 Human
  UniProt ID O95471
• Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets; and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies; including breast cancer; ovarian cancer; hepatocellular carcinomas; urinary tumors; prostate cancer; lung cancer; head and neck cancers; thyroid carcinomas; etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
• Synonyms: CEPTRL2; claudin-1; CLDN-7; CPETRL2; Hs.84359

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction