ADAM10 Rabbit Polyclonal Antibody

CAT#: TA323231

Anti-ADAM10 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 209 amino acids of human ADAM metallopeptidase domain 10
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ADAM metallopeptidase domain 10
• Database Link:
  NP_001101
  Entrez Gene 11487 MouseEntrez Gene 29650 RatEntrez Gene 102 Human
  UniProt ID O14672
• Background: This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.?Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. Sheddase, a generic name for the ADAM metallopeptidase, functions primarily to cleave membrane proteins at the cellular surface. Once cleaved, the sheddases release soluble ectodomains with an altered location and function.
• Synonyms: AD10; AD18; CD156c; HsT18717; kuz; MADM; RAK

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection