Angiopoietin like 4 (ANGPTL4) Rabbit Polyclonal Antibody

CAT#: TA323378

Anti-ANGPTL4 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 25-100
Positive control: Human esophagus cancer
Predicted cell location: Cytoplasm, Cell membrane
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Full length fusion protein
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name angiopoietin like 4
Background This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated; secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis; lipid metabolism; and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
Synonyms ANGPTL2; ARP4; FIAF; HFARP; PGAR; pp1158; PPARG
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways PPAR signaling pathway

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