Angiopoietin like 4 (ANGPTL4) Rabbit Polyclonal Antibody

CAT#: TA323378

Anti-ANGPTL4 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA323378 (ANGPTL4 Antibody) at dilution 1/25. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: angiopoietin like 4
• Database Link:
  NP_057193
  Entrez Gene 57875 MouseEntrez Gene 362850 RatEntrez Gene 51129 Human
  UniProt ID Q9BY76
• Background: This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated; secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis; lipid metabolism; and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
• Synonyms: ANGPTL2; ARP4; FIAF; HFARP; PGAR; pp1158; PPARG

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: PPAR signaling pathway