RRM1 Rabbit Polyclonal Antibody

CAT#: TA323396

Anti-RRM1 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 500-2000
WB positive control: Hela cells
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to C terminal 226 amino acids of human ribonucleotide reductase M1
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 90 kDa
Gene Name ribonucleotide reductase catalytic subunit M1
Background This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase; an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5; an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome; Wilms tumor; rhabdomyosarcoma; adrenocrotical carcinoma; and lung; ovarian; and breast cancer. This gene may play a role in malignancies and disease that involve this region.
Synonyms R1; RIR1; RR1
Reference Data
Protein Families Druggable Genome
Protein Pathways Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

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