Neuropilin 1 (NRP1) Rabbit Polyclonal Antibody

CAT#: TA323407

Anti-NRP1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human esophagus cancer
  Predicted cell location: cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 300 amino acids of human neuropilin 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: neuropilin 1
• Database Link:
  NP_003864
  Entrez Gene 18186 MouseEntrez Gene 246331 RatEntrez Gene 8829 Human
  UniProt ID O14786
• Background: This gene encodes one of two neuropilins; which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain; made up of complement-binding; coagulation factor V/VIII; and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival; migration; and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
• Synonyms: BDCA4; CD304; NP1; NRP; VEGF165R

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Axon guidance