RSK1 p90 (RPS6KA1) Rabbit Polyclonal Antibody

CAT#: TA323476

Anti-RPS6KA1 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 83 kDa. Positive control: Hela and NIH/3T3 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane 1, 2: Hela and NIH/3T3 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

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  Predicted cell location: Nucleus; Cytoplasm. Positive control: Hela cells. Recommended dilution: 1/ 100-200.The image is immunofluorescence of methanol-fixed Hela cells using RPS6KA1 antibody at dilution 1/100. (Original magnification: ×200)

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1:500-1000, IF: 1:100-200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide sequence around aa.346~350 (S-R-T-P-R) derived from Human RPS6KA1.
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 83 kDa
• Gene Name: ribosomal protein S6 kinase A1
• Database Link:
  NP_001006666
  Entrez Gene 20111 MouseEntrez Gene 81771 RatEntrez Gene 6195 Human
  UniProt ID Q15418
• Background: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
• Synonyms: HU-1; MAPKAPK1A; p90Rsk; RSK; RSK1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Long-term potentiation, MAPK signaling pathway, mTOR signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation