SMAD1 Rabbit Polyclonal Antibody

CAT#: TA323505

Anti-SMAD1 (Phospho-Ser206) Rabbit Polyclonal Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:500-1000
Reactivities Human, Mouse, Rat
Modifications Phospho-specific
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of serine 206 (P-H-S(p)-P-T) derived from Human Smad1.
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 52 kDa
Gene Name SMAD family member 1
Background The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Synonyms BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1
Reference Data
Protein Families Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
Protein Pathways TGF-beta signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.