ACTH (POMC) Rabbit Polyclonal Antibody

CAT#: TA323524

Anti-POMC Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse liver tissue and Mouse skeletal muscle tissue lysates
  IHC: 25-50
  Positive control: Human colorectal cancer
  Predicted cell location: Secreted
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 253-267 amino acids of human proopiomelanocortin
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 30 kDa
• Gene Name: proopiomelanocortin
• Database Link:
  NP_000930
  Entrez Gene 18976 MouseEntrez Gene 24664 RatEntrez Gene 5443 Human
  UniProt ID P01189
• Background: This gene encodes a polypeptide hormone precursor that undergoes extensive; tissue-specific; post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and; depending on tissue type and the available convertases; processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin; essential for normal steroidogenesis and the maintenance of normal adrenal weight; and lipotropin beta are the major end products. In other tissues; including the hypothalamus; placenta; and epithelium; all cleavage sites may be used; giving rise to peptides with roles in pain and energy homeostasis; melanocyte stimulation; and immune modulation.
• Synonyms: ACTH; CLIP; LPH; MSH; NPP; POC

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Melanogenesis