ACTH (POMC) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB: 500-2000 WB positive control: Human fetal brain tissue |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide peptide corresponding to a region derived from 136-150 amino acids of human proopiomelanocortin |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 29 kDa |
Gene Name | proopiomelanocortin |
Database Link | |
Background | This gene encodes a polypeptide hormone precursor that undergoes extensive; tissue-specific; post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and; depending on tissue type and the available convertases; processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin; essential for normal steroidogenesis and the maintenance of normal adrenal weight; and lipotropin beta are the major end products. In other tissues; including the hypothalamus; placenta; and epithelium; all cleavage sites may be used; giving rise to peptides with roles in pain and energy homeostasis; melanocyte stimulation; and immune modulation. |
Synonyms | ACTH; CLIP; LPH; MSH; NPP; POC |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Adipocytokine signaling pathway, Melanogenesis |
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