GAS 6 (GAS6) Rabbit Polyclonal Antibody

CAT#: TA323562

Anti-GAS6 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 10-50
  Positive control: Human ovarian cancer
  Predicted cell location: Cytoplasm, Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 690-705 amino acids of Human growth arrest-specific 6
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: growth arrest specific 6
• Database Link:
  NP_000811
  Entrez Gene 14456 MouseEntrez Gene 58935 RatEntrez Gene 2621 Human
  UniProt ID Q14393
• Background: This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation; and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Ligand for tyrosine-protein kinase receptors AXL; TYRO3 and MER whose signaling is implicated in cell growth and survival; cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis; optimal cytokine signaling during human natural killer cell development; hepatic regeneration; gonadotropin-releasing hormone neuron survival and migration; platelet activation; or regulation of thrombotic responses.
• Synonyms: AXLLG; AXSF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein