Angiotensin Converting Enzyme 1 (ACE) Rabbit Polyclonal Antibody

CAT#: TA323566

Anti-ACE1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Mouse kidney tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 78-92 amino acids of Human Angiotensin-converting enzyme
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 150 kDa
• Gene Name: angiotensin I converting enzyme
• Database Link:
  NP_000780
  Entrez Gene 11421 MouseEntrez Gene 24310 RatEntrez Gene 1636 Human
  UniProt ID P12821
• Background: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified; and two most abundant spliced variants encode the somatic form and the testicular form; respectively; that are equally active.
• Synonyms: ACE1; CD143; DCP; DCP1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protease, Secreted Protein, Transmembrane
• Protein Pathways: Hypertrophic cardiomyopathy (HCM), Renin-angiotensin system