Angiotensin Converting Enzyme 1 (ACE) Rabbit Polyclonal Antibody

CAT#: TA323567

Anti-ACE1 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Product Images

Specifications

Product Data
Applications WB
Recommended Dilution WB: 1000-5000
WB positive control: Mouse kidney tissue
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 78-92 amino acids of Human Angiotensin-converting enzyme
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 150 kDa
Gene Name angiotensin I converting enzyme
Background This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified; and two most abundant spliced variants encode the somatic form and the testicular form; respectively; that are equally active.
Synonyms ACE1; CD143; DCP; DCP1
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protease, Secreted Protein, Transmembrane
Protein Pathways Hypertrophic cardiomyopathy (HCM), Renin-angiotensin system

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