Glutathione Reductase (GSR) Rabbit Polyclonal Antibody

CAT#: TA323576

Anti-GSR Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Jurkat, Hela and A549 cells
  IHC: 50-200
  Positive control: Human ovarian cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 274-475 amino acids of human glutathione reductase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 56 kDa
• Gene Name: glutathione reductase
• Database Link:
  NP_000628
  Entrez Gene 14782 MouseEntrez Gene 116686 RatEntrez Gene 2936 Human
  UniProt ID P00390
• Background: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense; and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH; which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
• Synonyms: HEL-75

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glutathione metabolism