TGF beta 1 (TGFB1) Rabbit Polyclonal Antibody

CAT#: TA323601

Anti-TGFB1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323601 (TGFB1 Antibody) at dilution 1/20 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323601 (TGFB1 Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA323601 (TGFB1 Antibody) at dilution 1/20 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA323601 (TGFB1 Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Secreted, Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 30-278 amino acids of human transforming growth factor, beta 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transforming growth factor beta 1
• Database Link:
  NP_000651
  Entrez Gene 21803 MouseEntrez Gene 59086 RatEntrez Gene 7040 Human
  UniProt ID P01137
• Background: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines; which are multifunctional peptides that regulate proliferation; differentiation; adhesion; migration; and other functions in many cell types. Many cells have TGFB receptors; and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide; and is found in either a latent form composed of a TGFB1 homodimer; a LAP homodimer; and a latent TGFB1-binding protein; or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells; and mutations in this gene result in Camurati-Engelmann disease.
• Synonyms: CED; DPD1; LAP; TGFB; TGFbeta

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transcription Factors
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway