TGF beta 1 (TGFB1) Rabbit Polyclonal Antibody

CAT#: TA323601

Anti-TGFB1 Rabbit Polyclonal Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 25-100
Positive control: Human liver cancer
Predicted cell location: Secreted, Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to a region derived from 30-278 amino acids of human transforming growth factor, beta 1
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name transforming growth factor beta 1
Background This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines; which are multifunctional peptides that regulate proliferation; differentiation; adhesion; migration; and other functions in many cell types. Many cells have TGFB receptors; and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide; and is found in either a latent form composed of a TGFB1 homodimer; a LAP homodimer; and a latent TGFB1-binding protein; or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells; and mutations in this gene result in Camurati-Engelmann disease.
Synonyms CED; DPD1; LAP; TGFB; TGFbeta
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transcription Factors
Protein Pathways Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.