PMS1 Rabbit Polyclonal Antibody

CAT#: TA323629

Anti-PMS1 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 106 kDa. Positive control: HeLa, Jurkat, Molt-4 and HepG2 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane 1: HeLa cell lysate Lane 2: Jurkat cell lysate Lane 3: Molt-4 cell lysate Lane 4: HepG2 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Rabbit
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to N terminal 300 amino acids of human PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 106 kDa
• Gene Name: PMS1 homolog 1, mismatch repair system component
• Database Link:
  NP_000525
  Entrez Gene 5378 Human
  UniProt ID P54277
• Background: PMS1 belongs to the DNA mismatch repair mutL/hexB family. It is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in PMS1 cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other proteins involved in the HNPCC phenotype, which is also known as Lynch syndrome.
• Synonyms: HNPCC3; hPMS1; MLH2; PMSL1

Reference Data

• Protein Families: Druggable Genome, Transcription Factors