TIE2 (TEK) Rabbit Polyclonal Antibody

CAT#: TA323651

Anti-TEK Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Product Images

Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 50-200
Positive control: Human liver cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 516-529 amino acids of human TEK tyrosine kinase, endothelial
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name TEK receptor tyrosine kinase
Background The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice; rats; and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Synonyms CD202B; TIE-2; TIE2; VMCM; VMCM1
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

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