TIE2 (TEK) Rabbit Polyclonal Antibody

CAT#: TA323651

Anti-TEK Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 516-529 amino acids of human TEK tyrosine kinase, endothelial
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TEK receptor tyrosine kinase
• Database Link:
  NP_000450
  Entrez Gene 21687 MouseEntrez Gene 89804 RatEntrez Gene 7010 Human
  UniProt ID Q02763
• Background: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice; rats; and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
• Synonyms: CD202B; TIE-2; TIE2; VMCM; VMCM1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane