IL2 Receptor alpha (IL2RA) Rabbit Polyclonal Antibody

CAT#: TA323669

Anti-IL2RA Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323669 (IL2RA Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323669 (IL2RA Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm, Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 260-272 amino acids of Human interleukin 2 receptor, alpha
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 2 receptor subunit alpha
• Database Link:
  NP_000408
  Entrez Gene 16184 MouseEntrez Gene 25704 RatEntrez Gene 3559 Human
  UniProt ID P01589
• Background: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains; together with the common gamma chain (IL2RG); constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor; while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein; soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated; but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency
• Synonyms: CD25; IDDM10; IL2R; p55; TCGFR

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Jak-STAT signaling pathway