AIRE Rabbit Polyclonal Antibody

CAT#: TA323676

Anti-AIRE Rabbit Polyclonal Antibody

Product Images

Predicted band size: 58 kDa. Positive control: MCF7, U937, HT29, OVCAR3 and SW620 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane 1: MCF7 cell lysate Lane 2: U937 cell lysate Lane 3: HT29 cell lysate Lane 4: OVCAR3 cell lysate Lane 5: SW620 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 79-92 amino acids of human autoimmune regulator
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58 kDa
• Gene Name: autoimmune regulator
• Database Link:
  NP_000374
  Entrez Gene 11634 MouseEntrez Gene 294328 RatEntrez Gene 326 Human
  UniProt ID O43918
• Background: This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
• Synonyms: AIRE1; APECED; APS1; APSI; PGA1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Primary immunodeficiency, Ubiquitin mediated proteolysis