Apolipoprotein B (APOB) Rabbit Polyclonal Antibody

CAT#: TA323678

Anti-APOB Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 15-50
Positive control: Human colon cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 2158-2177 amino acids of human apolipoprotein B (including Ag(x) antigen)
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name apolipoprotein B
Background This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms; apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single; very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA); resulting in the creation of a stop codon; and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia; normotriglyceridemic hypobetalipoproteinemia; and hypercholesterolemia due to ligand-defective apoB; diseases affecting plasma cholesterol and apoB levels.
Synonyms FLDB; LDLCQ4
Reference Data
Protein Families Druggable Genome, Transmembrane

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