TPM1 Rabbit Polyclonal Antibody

CAT#: TA323684

Anti-TPM1 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Other products for "TPM1"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 1000-5000
WB positive control: Mouse heart tissue
IHC: 50-200
Positive control: Human breast cancer
Predicted cell location: Cytoplasm, cytoskeleton
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Full length fusion protein
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 33 kDa
Gene Name tropomyosin 1 (alpha)
Background This gene is a member of the tropomyosin family of highly conserved; widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle; where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells; alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.?
Synonyms C15orf13; CMD1Y; CMH3; HEL-S-265; HTM-alpha; LVNC9; TMSA
Reference Data
Protein Families Druggable Genome
Protein Pathways Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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