Tyrosine Hydroxylase (TH) Rabbit Polyclonal Antibody

CAT#: TA323691

Anti-TH (Phospho-Ser31) Rabbit Polyclonal Antibody

Product Images

Predicted band size: 59 kDa. Positive control: 293 cells treated with Doxorubicin lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane 1: 293 cells untreated with Doxorubicin lysate Lane 2: 293 cells treated with Doxorubicin lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1000
• Reactivities: Human, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of serine31(V-T-S(p)-P-R) derived from human Tyrosine Hydroxylase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa
• Gene Name: tyrosine hydroxylase
• Database Link:
  NP_000351
  Entrez Gene 25085 RatEntrez Gene 7054 Human
  UniProt ID P07101
• Background: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
• Synonyms: DYT5b; DYT14; TYH

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Parkinson's disease, Tyrosine metabolism