LAMA3 Rabbit Polyclonal Antibody

CAT#: TA323710

Anti-LAMA3 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 102-114 amino acids of Human laminin, alpha 3
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: laminin subunit alpha 3
• Database Link:
  NP_000218
  Entrez Gene 16774 MouseEntrez Gene 307582 RatEntrez Gene 3909 Human
  UniProt ID Q16787
• Background: Laminins are basement membrane components thought to mediate the attachment; migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5; which is a complex glycoprotein composed of three subunits (alpha; beta; and gamma). Laminin 5 is thought to be involved in cell adhesion; signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
• Synonyms: BM600; E170; LAMNA; LOCS

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer