Growth hormone receptor (GHR) Rabbit Polyclonal Antibody

CAT#: TA323722

Anti-GHR Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: PC cell
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 48-63 amino acids of Human growth hormone receptor
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 69 kDa
• Gene Name: growth hormone receptor
• Database Link:
  NP_000154
  Entrez Gene 14600 MouseEntrez Gene 25235 RatEntrez Gene 2690 Human
  UniProt ID P10912
• Background: This gene encodes a member of the type I cytokine receptor family; which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome; also known as the growth hormone insensitivity syndrome (GHIS); a disorder characterized by short stature. In humans and rabbits; but not rodents; growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
• Synonyms: GHBP; GHIP

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction