p57 Kip2 (CDKN1C) Rabbit Polyclonal Antibody

CAT#: TA323746

Anti-CDKN1C Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human colorectal cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1-14 amino acids of human cyclin-dependent kinase inhibitor 1C (p57, Kip2)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cyclin-dependent kinase inhibitor 1C
• Database Link:
  NP_000067
  Entrez Gene 12577 MouseEntrez Gene 246060 RatEntrez Gene 1028 Human
  UniProt ID P49918
• Background: This gene is imprinted; with preferential expression of the maternal allele. The encoded protein is a tight-binding; strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome; suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
• Synonyms: BWCR; BWS; KIP2; p57; p57Kip2; WBS

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle