p57 Kip2 (CDKN1C) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | IHC |
Recommended Dilution | IHC: 50-200 Positive control: Human colorectal cancer Predicted cell location: Nucleus |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 1-14 amino acids of human cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | cyclin-dependent kinase inhibitor 1C |
Database Link | |
Background | This gene is imprinted; with preferential expression of the maternal allele. The encoded protein is a tight-binding; strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome; suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. |
Synonyms | BWCR; BWS; KIP2; p57; p57Kip2; WBS |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Cell cycle |
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