ADA Rabbit Polyclonal Antibody

CAT#: TA323764

Anti-ADA rabbit polyclonal antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Raji cells
  IHC: 15-50
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 250 amino acids of human adenosine deaminase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 41 kDa
• Gene Name: adenosine deaminase
• Database Link:
  NP_000013
  Entrez Gene 11486 MouseEntrez Gene 24165 RatEntrez Gene 100 Human
  UniProt ID P00813
• Background: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.
• Synonyms: adenosine aminohydrolase; adenosine deaminase

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Primary immunodeficiency, Purine metabolism