Haptoglobin (HP) Rabbit Polyclonal Antibody

CAT#: TA323811

Anti-HP Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 30 μg Lane: Human brain glioma tissue Primary antibody: TA323811 (HP Antibody) at dilution 1/400 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 seconds

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323811 (HP Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323811 (HP Antibody) at dilution 1/25, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA323811 (HP Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA323811 (HP Antibody) at dilution 1/25, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human brain gliomas tissue
  IHC: 25-100
  Positive control: Human lung cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 162-406 amino acids of human haptoglobin
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 kDa
• Gene Name: haptoglobin
• Database Link:
  NP_001119574
  Entrez Gene 15439 MouseEntrez Gene 24464 RatEntrez Gene 3240 Human
  UniProt ID P00738
• Background: This gene encodes a preproprotein; which is processed to yield both alpha and beta chains; which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin; which allows degradative enzymes to gain access to the hemoglobin; while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy; the incidence of coronary artery disease in type 1 diabetes; Crohn's disease; inflammatory disease behavior; primary sclerosing cholangitis; susceptibility to idiopathic Parkinson's disease; and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: BP; HP2ALPHA2; HPA1S

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane