HP1 alpha (CBX5) Rabbit Polyclonal Antibody

CAT#: TA323817

Anti-CBX5 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Jurkat and Raji cell lysates
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kDa
• Gene Name: chromobox 5
• Database Link:
  NP_001120793
  Entrez Gene 12419 MouseEntrez Gene 300266 RatEntrez Gene 23468 Human
  UniProt ID P45973
• Background: This gene encodes a highly conserved nonhistone protein; which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues; and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants; encoding the same protein; have been identified.
• Synonyms: HEL25; HP1; HP1A