TRP2 (DCT) Rabbit Polyclonal Antibody

CAT#: TA323828

Anti-DCT Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human liver cancer and fetal liver tissue
  IHC: 50-200
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 222-472 amino acids of human dopachrome tautomerase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa
• Gene Name: dopachrome tautomerase
• Database Link:
  NP_001123361
  Entrez Gene 13190 MouseEntrez Gene 290484 RatEntrez Gene 1638 Human
  UniProt ID P40126
• Background: Dopachrome tautomerase (dopachrome delta-isomerase; tyrosine-related protein 2); also known as?DCT; is a human?gene. The human TYRP2 protein has 83% identity and 90% similarity to the mouse sequence and has all the structural characteristics of the tyrosinase protein family; including a signal peptide; 15 conserved cysteine residues; 2 copper-binding domains; and a C-terminal membrane-spanning region. Northern blot analysis showed that TYRP2 is expressed at high levels in human melanoma cells. Its expression is regulated by the microphthalmia-associated transcription factor (MITF).
• Synonyms: TRP-2; TYRP2

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Melanogenesis, Metabolic pathways, Tyrosine metabolism