OGA Rabbit Polyclonal Antibody
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Other products for "OGA"
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | WB: 500-2000 WB positive control: Mouse skin tissue lysate IHC: 100-300 Positive control: Human colorectal cancer Predicted cell location: Cytoplasm and Nucleus |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Fusion protein corresponding to a region derived from 695-814 amino acids of human meningioma expressed antigen 5 (hyaluronidase) |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 103 kDa |
Gene Name | meningioma expressed antigen 5 (hyaluronidase) |
Database Link | |
Background | The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT; which adds O-GlcNAc; and MGEA5; a glycosidase that removes O-GlcNAc modifications. Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. Shows highest expression in the brain; placenta and pancreas. |
Synonyms | MEA5; NCOAT; OGA |
Reference Data |
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