CDK5 Rabbit Polyclonal Antibody

CAT#: TA323961

Anti-CDK5 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Jurkat and NIH/3T3 cells
  IHC: 25-100
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm or Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 33 kDa
• Gene Name: cyclin-dependent kinase 5
• Database Link:
  NP_001157882
  Entrez Gene 12568 MouseEntrez Gene 140908 RatEntrez Gene 1020 Human
  UniProt ID Q00535
• Background: Cell division protein kinase 5?is an?enzyme?that in humans is encoded by the?CDK5?gene.?The protein encoded by this gene is part of the?cyclin-dependent kinase?family. CDK5 is required for proper development of the brain and to be activated; CDK5 must associate with CDK5R1 or CDK5R2. Cdk5 is involved in the processes of neuronal maturation and migration; phosphorylating the key intracellular adaptor of the reelin signaling chain. Experiments performed on mice lacking p35; a necessary activator of cdk5 in early brain development; showed that the normal layering of neurons was reversed in the cortex. This disrupted lamination again implicated cdk5 in neuronal migration and plasticity. Cdk5 is also involved in the regulation of synaptic vesicle exocytosis via phosphorylation of munc-18.
• Synonyms: PSSALRE

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Alzheimer's disease, Axon guidance