FHIT Rabbit Polyclonal Antibody

CAT#: TA323982

Anti-FHIT Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse brain and human fetal kidney tissue
  IHC: 25-100
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 17 kDa
• Gene Name: fragile histidine triad
• Database Link:
  NP_001159715
  Entrez Gene 14198 MouseEntrez Gene 60398 RatEntrez Gene 2272 Human
  UniProt ID P49789
• Background: This gene; a member of the histidine triad gene family; encodes a diadenosine 5';5'''-P1;P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3; where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact; aberrant transcripts from this gene have been found in about half of all esophageal; stomach; and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
• Synonyms: AP3Aase; FRA3B

Reference Data

• Protein Pathways: Non-small cell lung cancer, Purine metabolism, Small cell lung cancer