IDE Rabbit Polyclonal Antibody

CAT#: TA323993

Anti-IDE Rabbit Polyclonal Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 500-2000
WB positive control: K562 cells
IHC: 10-50
Positive control: Human colon cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to a C terminal 300 amino acids of human insulin-degrading enzyme
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 118 kDa
Gene Name insulin degrading enzyme
Background This gene encodes a zinc metallopeptidase that degrades intracellular insulin; and thereby terminates insulins activity; as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon; amylin; bradykinin; and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space; cell membrane; peroxisome; and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
Synonyms INSULYSIN
Reference Data
Protein Families Druggable Genome, Protease
Protein Pathways Alzheimer's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.