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Acinus (ACIN1) Rabbit Polyclonal Antibody
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Specifications
| Product Data | |
| Applications | IHC |
| Recommended Dilution | IHC: 100-300 Positive control: Human liver cancer Predicted cell location: Nucleus, Cytoplasm |
| Reactivities | Human, Mouse, Rat |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 1065-1080 amino acids of human apoptotic chromatin condensation inducer 1 |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | apoptotic chromatin condensation inducer 1 |
| Database Link | |
| Background | Apoptosis is defined by several morphologic nuclear changes; including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3; without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs; as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Synonyms | ACINUS; ACN; fSAP152 |
| Reference Data | |
| Protein Pathways | Spliceosome |
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